| | 1431612-23-5 Basic information More.. |
| Product Name: | UNC 1999 | | Synonyms: | 1H-Indazole-4-carboxamide, N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-;N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide UNC1999;UNC 1999;UNC1999;UNC-1999;N-[(1,2-Dihydro-6-Methyl-2-oxo-4-propyl-3-pyridinyl)Methyl]-1-(1-Methylethyl)-6-[6-[4-(1-Methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxaMide;1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide;UNC1999;UNC-1999;UNC 1999 | | CAS: | 1431612-23-5 | | MF: | C33H43N7O2 | | MW: | 569.74 | | EINECS: | | | Mol File: | 1431612-23-5.mol |  |
Use
UNC1999 is highly potent for both EZH2 Y641N and EZH2 Y641F mutants in vitro. UNC1999 causes concentration-dependent reductions of H3K27me3 in MCF10A cells with IC50 of 124 nM , while shows low cellular toxicity. UNC1999 displays potent, concentration-dependent inhibition of cell proliferation with EC50 of 633 nM in a DLBCL cell line harboring the EZH2Y641N mutant. In addition, biotinylated UNC1999 enriches EZH2 from HEK293T cell lysates, and thus may be used in chemoproteomics studies.
- UNC1999
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- US $0.00-0.00 / KG
- 2021-07-20
- CAS:1431612-23-5
- Min. Order: 5mg
- Purity: 99%HPLC
- Supply Ability: 2000tons
- UNC 1999
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- US $1.00 / g
- 2019-12-24
- CAS:1431612-23-5
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 20kg
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1431612-23-5
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