| | 978-62-1 Basic information More.. |
| Product Name: | IMD-0354 | | Synonyms: | Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-;N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354;IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem;IKK-2 INHIBITOR V; IMD 0354;IMD0354;;IMD-0354, 99%, a synthetic selective NF-kB inhibitor;IMD 0354;IMD-0354;IMD-0354 USP/EP/BP;IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354 | | CAS: | 978-62-1 | | MF: | C15H8ClF6NO2 | | MW: | 383.67 | | EINECS: | | | Mol File: | 978-62-1.mol |  |
Use
IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury. IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis. It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 μM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.
- IMD-0354
-
- US $1.00 / KG
- 2020-02-20
- CAS:978-62-1
- Min. Order: 1KG
- Purity: 98% HPLC
- Supply Ability: 10 Tons
|
|
978-62-1
Recommend Suppliers |
|