FLUMICLORAC-PENTYL

Use

In the feces and urine of rats, more than 90% of administered 14C-flumiclorac pentyl is excreted within 48 h of treatment. Flumiclorac pentyl is rapidly and extensively metabolized. The major fecal metabolites are identified as the sulfonic acid conjugates, and the major urinary metabolite is identified as 5-amino-2- chloro-4-fluorophenoxyacetic acid. The metabolic reactions include cleavage of the ester linkage, cleavage of the imide linkage, hydroxylation and following reduction at the cyclohexene ring of the cyclohexene- 1,2-dicarboxylic acid moiety, and incorporation of a sulfonic acid group into the carbon ? carbon double bond of the 3,4,5,6-tetrahydrophthalimide moiety.