| | 146939-27-7 Basic information More.. |
| Product Name: | Ziprasidone | | Synonyms: | Ziprasidone;CP-88059：CP-88059-1;1,2-Benzisothiazole, 3-(1-piperazinyl)-, monohydrochlorideH-indol-2-one, 6-chloro-5-(2-chloroethyl)-1,3-dihydro;5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one;Ziprasidone HBr;5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-2,3-dihydro-1H-indol-2-one;Ziprasidone solution;5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one | | CAS: | 146939-27-7 | | MF: | C21H21ClN4OS | | MW: | 412.94 | | EINECS: | 203-794-9 | | Mol File: | 146939-27-7.mol |  |
Use
Ziprasidone, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, is available as the hydrochloride monohydrate for oral administration (Geodon) and as the mesylate trihydrate saltfor intramuscular (IM) injection. The compound is well absorbedwith peak plasma levels occurring at 6 to 8 hours afteroral administration. The oral absorption is enhanced approximatelytwofold in the presence of food. Ziprasidone isbound about 99% to plasma proteins, primarily to albuminand α1-acid glycoprotein. Ziprasidone is not displaced in thepresence of two highly protein bound drugs, warfarin andpropranolol. Ziprasidone is extensively metabolized withonly about 5 % of the drug excreted unchanged.23 In humans,two major pathways are responsible for the metabolism ofziprasidone: (a) oxidation by CYP3A4 (one third) and (b) reductionby aldehyde oxidase (two thirds).The combinedaction of these metabolic pathways leads to four majorcirculating metabolites: benzisothiazole piperazine sulfoxide(BITP-sulfoxide), benzisothiazole piperazine sulfone (BITPsulfone),ziprasidone sulfoxide, and S-methyldihydroziprasidone.
- Ziprasidone
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- US $1.00-0.50 / kg
- 2024-06-07
- CAS:146939-27-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 200
- Ziprasidone
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- US $16.00 / KG
- 2024-01-18
- CAS:146939-27-7
- Min. Order: 1KG
- Purity: 99.90%
- Supply Ability: 20T
- Ziprasidone
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- US $200.00 / kg
- 2023-06-26
- CAS:146939-27-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg/Month
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146939-27-7
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