| | 339177-26-3 Basic information More.. |
| Product Name: | Panitumumab | | Synonyms: | Panitumumab;Abx-egf;Abx-egf mab;Immunoglobulin, anti-(human epidermal growth factor receptor) (human monoclonal abx-egf heavy chain), disulfide with human monoclonal abx-egf light chain, dimer;Unii-6A901E312a;Vectibix;Abenix;Panitumumab USP/EP/BP | | CAS: | 339177-26-3 | | MF: | | | MW: | 0 | | EINECS: | | | Mol File: | Mol File |  |
Use
Panitumumab is a recombinant, fully human IgG2 kappa monoclonal antibody
that is highly selective for the epidermal growth factor receptor (EGFR),
and it is indicated for the treatment of EGFR-expressing, metastatic colorectal
carcinoma (mCRC) with disease progression on or following fluoropyrimidine-,
oxaliplatin-, and irinotecan-containing chemotherapy regimens. Overexpression
of EGFR is detected in many human cancers, including those of the colon and
rectum. Panitumumab blocks the binding of ligands such as epidermal growth
factor (EGF) and transforming growth factor (TGF-a) to various EGFR-expressing
cell lines, which results in inhibition of EGF-dependent tumor cell activation,
induction of apoptosis, and decreased pro-inflammatory cytokine and vascular
growth factor production. In vitro, panitumumab binds EGFR with high affinity
(KD ? 50pM; IC50 ? 3 nM) in human cervical epidermal cell line A-431.
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- Panitumumab USP/EP/BP
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- US $1.10 / g
- 2021-07-03
- CAS:339177-26-3
- Min. Order: 1g
- Purity: 99.9%
- Supply Ability: 100 Tons Min
- Panitumumab
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- US $0.00-0.00 / Kg
- 2020-05-03
- CAS:339177-26-3
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 800 ton
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339177-26-3
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