Use
Flosequinan is a new mixed arteriolar and venous vasodilator useful for the treatment
of patients with congestive heart failure with or without ACE inhibitors, but especially
in those patients who are intolerant to ACE inhibitors. It does not cause reflex
stimulation of the renin-angiotensin or sympathetic nervous system. How flosequinan
achieves its direct vasodilating effect is not clear, it is thought to interfere with protein
kinase C and the production of inositol triphosphate. Flosequinan is well absorbed
orally, and with the relatively long half-life of its sulfone metabolite it is suitable for
once a day administration.