137213-91-3
| 中文名称 | 137213-91-3 |
|---|---|
| 中文同义词 | 化合物 T10562 |
| 英文名称 | (4-acetamidocyclohexyl) nitrate |
| 英文同义词 | (4-acetamidocyclohexyl) nitrate;Acetamide, N-[trans-4-(nitrooxy)cyclohexyl]-;(4Acetamidocyclohexyl) nitrate,(4 Acetamidocyclohexyl) nitrate |
| CAS号 | 137213-91-3 |
| 分子式 | C8H14N2O4 |
| 分子量 | 202.21 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 137213-91-3.mol |
| 结构式 |  |
137213-91-3 性质
| 沸点 | 378.8±22.0 °C(Predicted) |
|---|---|
| 密度 | 1.20±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 15.48±0.40(Predicted) |
(4-Acetamidocyclohexyl) nitrate (BM121307) 是一种鸟苷酸环化酶 (guanylate cyclase) 激活剂。
The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively.