| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:ANTI-MDM2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Monoclonal Anti-MDMX
Purity:monoclonal MDMX-82, purified from hybridoma cell culture Package:200μL Remarks:M0445
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| Company Name: |
Shanghai Huzhen Industrial Co., LTD
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| Tel: |
021-60345367 13916550749 |
| Email: |
sales@shzbio.com |
| Products Intro: |
Product Name:MDMX
Purity:> 99% Package:50ul/RMB 1138;100ul/RMB 1880;200ul/RMB 2900 Remarks:Double minute 4; Double minute 4 human homolog of p53 binding protein
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| | ANTI-MDM2 Basic information |
| Product Name: | ANTI-MDM2 | | Synonyms: | ANTI-UBIQUITIN PROTEIN LIGASE;ANTI-UBIQUITIN PROTEIN LIGASE (AB-1), HUMAN;p53-binding protein Mdm2;Ubiquitin-protein ligase E3 Mdm2;double minute 4 protein;Mdm2-like p53-binding protein;MDMX;p53-binding protein Mdm4 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-MDM2 Structure]() |
| | ANTI-MDM2 Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| | ANTI-MDM2 Usage And Synthesis |
| Uses | Monoclonal Anti-MDMX antibody is suitable for use in immunocytochemistry, immunoprecipitation, immunoblot (approx. 80 kDa), microarray, and ELISA. The product may also be used for western blot and for assessing ectopic expression of MDMX (using a conc. of 1-2 μg/mL in total cell extract of HEK 293T cells transfected with human MDMX). | | General Description | Monoclonal Anti-MDMDX (mouse IgG1 isotype) is derived from the hybridoma MDMX-82 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice. MDMX belongs to the MDM family. The MDMX/ mouse double minute 4 (MDM4) gene encode a 490 amino acid protein. MDMX comprises a putative nuclear localization signal, a really interesting new gene (RING) finger domain in the C terminal and a p53-binding domain in the N terminal. MDMX has significant structural similarity to MDM2 E3 ubiquitin ligase. | | Biochem/physiol Actions | MDMX is a structural homolog of MDM2 and inhibits the tumor suppressor, p53. MDMX also prevents MDM2-mediated degradation of p53, and subsequently regulates cellular levels of p53. MDMX also modulates cell growth and survival. Thus, MDMX can be useful as a therapeutic target in cancers, especially in tumors where native p53 functions can be restored . Monoclonal Anti-MDMX antibody is specific for human MDMX. |
| | ANTI-MDM2 Preparation Products And Raw materials |
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