| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:PAC-1-d8
CAS:1287241-26-2
Package:2.5Mg,25Mg
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:PAC-1-d8
CAS:1287241-26-2
Purity:NULL Package:2.5mg;25mg Remarks:NULL
|
|
| | PAC-1-d8 Basic information |
| | PAC-1-d8 Chemical Properties |
| solubility | soluble in DMSO, Methanol | | form | Solid | | color | Off-White |
| | PAC-1-d8 Usage And Synthesis |
| Uses | Labelled PAC-1 is a caspase 3 activator. Caspase activation is a key strategy in cancer therapy. Caspase 3 is a key executioner caspase and direct effector of apoptosis. Hallmark of many cancers is the circumvention of signal in the activation of executioner caspases and loss of apoptotic response. EC50 for caspase 3 activation = 0.33 μM and caspase 7= 4.5 μM. The IC50 for apoptosis induction = 0.92 μM. Elevated caspase 3 level in cancerous cell lines and tissues allows PAC-1 to selectively induce apoptosis in tissues. |
| | PAC-1-d8 Preparation Products And Raw materials |
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