Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:5-trans U-46619 CAS:330796-58-2 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
Tel: |
021-65675885 18964387627 |
Email: |
customer_service@efebio.com |
Products Intro: |
Product Name:5-trans U-46619 CAS:330796-58-2 Purity:98% Package:1mg;5mg;10mg
|
Company Name: |
ApexBio Technology
|
Tel: |
+ 1-832-696-8203 |
Email: |
sales@apexbt.com |
Products Intro: |
Product Name:5-trans U-46619 CAS:330796-58-2
|
Company Name: |
Cayman Chemical Company
|
Tel: |
(800) 364-9897 |
Email: |
cayman@caymanchem.com |
Products Intro: |
Product Name:5-trans U-46619 CAS:330796-58-2 Package:>98% Remarks:16452
|
|
| 5-TRANS U-46619 Basic information |
Product Name: | 5-TRANS U-46619 | Synonyms: | 5-TRANS U-46619;9,11-DIDEOXY-9ALPHA, 11ALPHA-METHANOEPOXY-PROSTA-5E,13E-DIEN-1-OIC ACID;LQANGKSBLPMBTJ-YTQMDITASA-N;5-Heptenoic acid, 7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-, (5E)- (9CI) | CAS: | 330796-58-2 | MF: | C21H34O4 | MW: | 350.49 | EINECS: | | Product Categories: | | Mol File: | Mol File | |
| 5-TRANS U-46619 Chemical Properties |
storage temp. | Store at -20°C | solubility | ≤100mg/ml in ethanol;100mg/ml in DMSO;100mg/ml in dimethyl formamide;2mg/ml in PBS(pH7.2) | form | solution in acetate. |
| 5-TRANS U-46619 Usage And Synthesis |
Uses | U-46619 is a TP receptor agonist that exhibits properties similar to Thromboxane A2, inducing platelet aggregation and vascular smooth muscle contraction. 5-trans U-46619 is a minor impurity (2-5%) which is variably present in most commercial preparations of U-46619. The biological activity of 5-trans U-46619 has rarely been tested separately from U-46619 itself. In the only case published to date, 5-trans U-46619 was found to be a about half as potent an inhibitor of Prostaglandin E synthase as the 5-cis version of U-46619.[Cayman Chemical] | Biological Activity | 5-trans u-46619 is a minor impurity (2-5%) which variably exists in most commercial preparations of u-46619 [1]. u-46619 is a selective thromboxane a2 agonist involved in inducing platelet aggregation and vascular smooth muscle contraction [2].the biological activity of 5-trans u-46619 has been rarely tested separately from u-46619 itself. in the only case published to date, 5-trans u-46619 was found to be a about half as potent an inhibitor of prostaglandin e synthase as the 5-cis version of u-46619 [1]. thromboxane a2 (txa2) has been involved in the pathogenesis of airway hyperresponsiveness. txa2 is a type of thromboxane produced by activated platelets and shows prothrombotic properties. thromboxane a2 has also been known as a vasoconstrictor and is especially important during tissue injury and inflammation [3]. | references | [1] quraishi o, mancini j a, riendeau d. inhibition of inducible prostaglandin e 2 synthase by 15-deoxy-δ 12, 14-prostaglandin j 2 and polyunsaturated fatty acids[j]. biochemical pharmacology, 2002, 63(6): 1183-1189. [2] coleman, r. a.,humphrey, p.p.a.,kennedy, i., et al. comparison of the actions of u-46619, a prostaglandin h2-analogue, with those of prostaglandin h2 and thromboxane a2 on some isolated smooth muscle preparations. british journal of pharmacology 73, 773-778 (1981). [3] svensson j, strandberg k, tuvemo t, et al. thromboxane a2: effects of airway and vascular smooth muscle[j]. prostaglandins, 1977, 14(3): 425-436. |
| 5-TRANS U-46619 Preparation Products And Raw materials |
|