SIB 1553A hydrochloride
中文名称 | SIB 1553A hydrochloride |
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中文同义词 | 化合物 T16881 |
英文名称 | SIB 1553A hydrochloride |
英文同义词 | SIB 1553A hydrochloride;4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol;(±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride;SIB 1553A Hyrdrochloride;4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol:hydrochloride;SIB 1553A,SIB1553A |
CAS号 | 191611-89-9 |
分子式 | C13H20ClNOS |
分子量 | 273.82 |
EINECS号 | |
相关类别 | |
Mol文件 | 191611-89-9.mol |
结构式 |
SIB 1553A hydrochloride 性质
熔点 | 149-151°C |
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储存条件 | Hygroscopic, Refrigerator, under inert atmosphere |
溶解度 | DMSO(少许)、水(少许) |
形态 | 固体 |
颜色 | 白色至类白色 |
水溶解性 | Soluble to 100 mM in water |
SIB-1553A displaces the binding of
[H]
nicotine (NIC) to the rat brain nAChRs with an IC
50
value of 110 nM.
In calcium flux assays, SIB-1553A (0.1-5 μM), shows a greater selectivity for beta4-subunit containing recombinant hnAChRs (alpha2beta4, alpha3beta4 and alpha4beta4) vs. beta2-subunit containing nAChRs (alpha4beta2 and alpha3beta2) both in terms of efficacy and potency.
SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels.
Animal Model: | Male Sprague-Dawley rats (200-250 g) |
Dosage: | 1, 2, 4, 10, 20 and 40 mg/kg |
Administration: | s.c. |
Result: | Induced hippocampal ACh release. |