Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride
生物活性体外研究体内研究 用途与合成方法 MSDS Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride价格(试剂级) 上下游产品信息
| 中文名称 | Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride |
|---|---|
| 中文同义词 | POZANICLINE DIHYDROCHLORIDE;化合物 T12525;(S)-2-甲基-3-(吡咯烷-2-基甲氧基)吡啶二盐酸盐;化合物POZANICLINE DIHYDROCHLORIDE;ABT 089 2HCL,Α4Β2NACHR部分激动剂 |
| 英文名称 | Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride |
| 英文同义词 | Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride;Pozanicline dihydrochloride;ABT 089 dihydrochloride;ABT 089 dihydrochloride (ABT089;2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride;receptor,nAChR,nicotinic,acetylcholine,ABT 089,inhibit,Pozanicline,Nicotinic acetylcholine receptors,Parkinson,disease,ABT-089,Pozanicline dihydrochloride,dopamine,Alzheimer,ABT089,Inhibitor;(S)-2-Methyl-3-(pyrrolidin-2-ylmethoxy)pyridine dihydrochloride |
| CAS号 | 161416-61-1 |
| 分子式 | C11H17ClN2O |
| 分子量 | 228.72 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 161416-61-1.mol |
| 结构式 | ![Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride 结构式](CAS/20180527/GIF/161416-61-1.gif) |
Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 旋光性 (optical activity) | [α]/D +20 to +30°, c = 1 in methanol |
Pozanicline dihydrochloride (ABT-089 dihydrochloride) 是一种具有口服活性的烟碱型乙酰胆碱受体 (nAChR) 激动剂，与 [3H] 胱氨酸位点结合，Ki 为 16.7 nM。Pozanicline dihydrochloride 是一种 α4β2 选择性 nAChR 激动剂，与大鼠脑 α4β2 nAChR 结合，Ki 为 17 nM，而与 α7nAChR 的结合力很弱。
Pozanicline (ABT-089) is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC
50
of 0.11 μM.
Pozanicline (ABT-089) shows high selectivity for α6β2 and α4α5β2 nAChR subtypes.
Pozanicline (ABT-089; 0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning.
| Animal Model: | Adult male C57BL6/J mice at 8-12 weeks of age. |
| Dosage: | 0.3 mg/kg and 0.6 mg/kg |
| Administration: | Treated 5 min before training and testing for contextual fear conditioning |
| Result: | A dose of 0.3 mg/kg and 0.6 mg/kg ameliorated nicotine withdrawal-induced cognitive deficits in contextual fear conditioning. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-110160 | Pozanicline dihydrochloride | 1 mg | 571元 | |
| 2024/04/30 | HY-110160 | Pyridine, 2-methyl-3-[(2S)-2-pyrrolidinylmethoxy]-, dihydrochloride Pozanicline dihydrochloride | 161416-61-1 | 5mg | 1500元 |