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| Product Name: | BTSA 1 | | Synonyms: | BTSA1 >=98% (HPLC);1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(2-thiazolyl)hydrazone];CS-2853;5-Phenyl-2-(4-phenyl-thiazol-2-yl)-4-(thiazol-2-yl-hydrazono)-2,4-dihydro-pyrazol-3-one;BTSA 1;BTSA-1;BTSA 1;inhibit,FITC-BIM,caspase-3/7,translocation,Bcl-2 Family,viability,Inhibitor,BTSA1,mitochondrial,pharmacologically,BAX,AML,BTSA 1,BTSA-1,SAHBA2,Apoptosis;5-Phenyl-2-(4-phenylthiazol-2-yl)-4-(2-(thiazol-2-yl)hydrazono)-2,4-dihydro-3H-pyrazol-3-one | | CAS: | 314761-14-3 | | MF: | C21H14N6OS2 | | MW: | 430.51 | | EINECS: | | | Product Categories: | API | | Mol File: | 314761-14-3.mol |  |
| | BTSA 1 Chemical Properties |
| Boiling point | 625.2±48.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO:53.0(Max Conc. mg/mL);123.11(Max Conc. mM) | | pka | 6.52±0.40(Predicted) |
| | BTSA 1 Usage And Synthesis |
| Biological Activity | BTSA1 is a BAX activator that binds to its N-terminal activation site with high affinity and specificity, induces a conformational change in BAX, and causes BAC-mediated apoptosis. It efficiently promotes apoptosis in leukemia cell lines and patient samples without affecting healthy cells. | | in vivo | BTSA1 effectively inhibits human acute myeloid leukemia xenografts and enhances host survival without toxic side effects. In mice, it was well tolerated. | | target |
| | BTSA 1 Preparation Products And Raw materials |
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Tag:BTSA 1(314761-14-3)
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