|
|
| | 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Basic information |
| | 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Chemical Properties |
| Melting point | 131-132°C | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White |
| | 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Usage And Synthesis |
| Description | Carisbamate is an antiepileptic agent., In vivo, administration of carisbamate (10-60 mg/kg) dose-dependently reduces spike and wave discharges in the frontoparietal cortex in a rat model of absence seizures. Carisbamate (10 mg/kg) increases latency to the first running episode in the Wistar audiogenic sensitive rat model of convulsive seizures. It also reduces motor seizure frequency in a rat model of spontaneous seizures in a dose-dependent manner. Carisbamate blocks Nav1.2 channels (IC50 = 68 μM for rat channels) and inhibits repetitive firing of action potentials in rat hippocampal neurons in a dose-dependent manner. It also reduces T-type Ca2+ currents in HEK cells transfected with human recombinant Cav3.1 channels at a concentration of 300 μM. | | Uses | Carisbamate is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizure models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models. | | Uses | Labelled Carisbamate; it is being developed for adjuvant treatment of partial onset epilepsy. Carisbamate produces anticonvulsant effects in primary generalized, complex partial and absence-type seizu
re models, and exhibits neuroprotective and antiepileptogenic properties in rodent epilepsy models. | | Definition | ChEBI: Carisbamate is an organochlorine compound. |
| | 2-(2-CHLOROPHENYL)-2-HYDROXYETHYL CARBAMATE Preparation Products And Raw materials |
|