| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:AureusiMine B
CAS:170713-71-0
Package:100Mg,10Mg
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| Company Name: |
AstaTech (Chengdu) Pharma. Co., Ltd.
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| Tel: |
028-85122536 15928766785 |
| Email: |
wupengcheng@astatech.cn |
| Products Intro: |
Product Name:3-(1-Methylethyl)-6-(phenylmethyl)-2(1H)-pyrazinone
CAS:170713-71-0
Purity:97% Package:250MG;1G;5G;25G Remarks:11617
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| Company Name: |
SanoChem (Chengdu) Tech. Co., Ltd.
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| Tel: |
28-87999436 02887999436 |
| Email: |
sales@sano-chem.com |
| Products Intro: |
CAS:170713-71-0
Purity:99% Package:100G;500G;1KG;5KG;25KG
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| | 3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone Basic information |
| | 3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone Chemical Properties |
| Melting point | 117-118 °C | | density | 1.10±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | pka | 11.65±0.60(Predicted) | | color | Off-White to Light Grey |
| | 3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone Usage And Synthesis |
| Description | Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears to be initiated by a conserved nonribosomal peptide synthetase that creates a dipeptide (phenylalanine-valine) aldehyde, which then undergoes cyclization and oxidation. Aureusimine B inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 μM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression. | | Uses | Aureusimine B is a novel small molecule isolated from S. aureus as one of a pair of related metabolites controversially identified as virulence factors in the pathology of Golden Staph. Aureusimine B
has also been reported as an inhibitor of the protease, calpain. | | Uses | Aureusimine B (phevalin) is a small molecular weight monoketopiperazine formed non-ribosomally by the fusion of phenylalanine and valine. Aureusimine B was isolated from S. aureus in 2010 as one of a pair of related metabolites, controversially identified as virulence factors in the pathology of Golden Staph. Aureusimine B is also an inhibitor of the protease, calpain. | | Definition | ChEBI: Phevalin is a member of the class of pyrazinones that is pyrazin-2(1H)-one substituted by an isopropyl and benzyl groups at position 3 and 6, respectively. It is a natural product found in Staphylococcus aureus that inhibits calpain in a casein hydrolysis assay (IC50 = 1.3 muM), contributes to S. aureus infection in mice, and alters human keratinocyte gene expression. It has a role as a bacterial metabolite and a calpain inhibitor. It is a member of benzenes and a pyrazinone. |
| | 3-(1-Methylethyl)-6-(phenylMethyl)-2(1H)-pyrazinone Preparation Products And Raw materials |
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