- Hydroxypioglitazone
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- $1.00 / 1kg
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2019-07-06
- CAS:146062-44-4
- Min. Order: 1kg
- Purity: 95%-99%
- Supply Ability: 100kg
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| | Hydroxypioglitazone Basic information |
| | Hydroxypioglitazone Chemical Properties |
| Melting point | 157-1580C | | Boiling point | 627.6±55.0 °C(Predicted) | | density | 1.325±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer, Under Inert Atmosphere | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | pka | 6.35±0.50(Predicted) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | CAS DataBase Reference | 146062-44-4 |
| | Hydroxypioglitazone Usage And Synthesis |
| Description | Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM). | | Chemical Properties | Off-White Solid | | Uses | A metabolite of Pioglitazone (P471000). | | Definition | ChEBI: Hydroxypioglitazone is a member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone. It has a role as a human xenobiotic metabolite. It is a member of thiazolidinediones, a member of pyridines and an aromatic ether. It is functionally related to a pioglitazone. |
| | Hydroxypioglitazone Preparation Products And Raw materials |
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