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| | SU 5205 Basic information |
| Product Name: | SU 5205 | | Synonyms: | SU 5205;2H-Indol-2-one, 3-[(4-fluorophenyl)methylene]-1,3-dihydro-;SU 5205; SU-5205; SU5205;mitogenesis,Inhibitor,VEGFR2,Vascular endothelial growth factor receptor,FLK-1,SU-5205,endothelial,VEGFR,SU5205,inhibit | | CAS: | 3476-86-6 | | MF: | C15H10FNO | | MW: | 239.24 | | EINECS: | | | Product Categories: | | | Mol File: | 3476-86-6.mol |  |
| | SU 5205 Chemical Properties |
| Melting point | 194-196 °C | | Boiling point | 435.3±45.0 °C(Predicted) | | density | 1.306±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 5 mg/ml | | form | A crystalline solid | | pka | 12.69±0.20(Predicted) |
| | SU 5205 Usage And Synthesis |
| Biological Activity | SU5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 9.6 μM. | | in vitro | SU5205 inhibits ligand-induced endothelial mitogenesis for VEGF with an IC 50 of 5.1 μM. | | target | | Target | Value | VEGFR2
(Cell-free assay) | 9.6 μM |
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| | SU 5205 Preparation Products And Raw materials |
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