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| Product Name: | Rbin-1 | | Synonyms: | Rbin-1;3-(2-methylprop-2-enylsulfanyl)-5H-[1,2,4]triazino[5,6-b]indole;Rbin-1 - Ribozinoindole-1;RBIN 1;RIBOZINOINDOLE 1;RBIN1;RIBOZINOINDOLE-1;RBIN-1;RIBOZINOINDOLE1;Ribozinoindole 1;Ribozinoindole1;Ribozinoindole-1;CS-2565 | | CAS: | 328023-11-6 | | MF: | C13H12N4S | | MW: | 256.33 | | EINECS: | | | Product Categories: | | | Mol File: | 328023-11-6.mol |  |
| | Rbin-1 Chemical Properties |
| Boiling point | 479.6±47.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | Soluble in DMSO (up to at least 25 mg/ml) | | pka | 10.34±0.50(Predicted) | | form | solid | | color | Pale yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | Rbin-1 Usage And Synthesis |
| Description | Rbin-1 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis. It inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM) and inhibits mdn1 ATPase activity by approximately 40% when used at a concentration of 1 μM. Rbin-1 inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts, but not mdn1-F1093L mutant, S. pombe cells. It also decreases ribosome assembly protein 4 (Rsa4) levels in Rix1 particles, a ribosome assembly intermediate, Rix1-bound Ytm1 levels, and Rix7 and Ppp1 levels in the nucleolar pre-60S particle Nsa1 in mdn1-ts fission yeast cells. | | Uses | 3-[(2-Methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole is a triazinoindole derivative that inhibits eukaryotic ribosome biogenesis (1). It is also an ATPase inhibitor (1). | | Definition | ChEBI: Ribozinoindole-1 is a triazinoindole that is 5H-[1,2,4]triazino[5,6-b]indole which is substituted at position 3 by a (2-methylprop-2-en-1-yl)thio group. A potent inhibitor of midasin which is an essential protein for eukaryotic ribosome biogenesis. It is a triazinoindole and an organic sulfide. | | References | 1) Kawashime?et al.?(2016),?Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis; Cell?167?512 |
| | Rbin-1 Preparation Products And Raw materials |
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