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| | NIH-12848 Basic information |
| Product Name: | NIH-12848 | | Synonyms: | NIH-12848;NIH-12848, 959551-10-1;4-Quinazolinamine, N-(2-thienylmethyl)-2-[2-(trifluoromethyl)phenyl]-;NIH-12848, >98%;NIH12848;NIH 12848;N-(thiophen-2-ylmethyl)-2-(2-(trifluoromethyl)phenyl)quinazolin-4-amine;NIH-12848,NIH12848,Inhibitor,inhibit,NIH 12848 | | CAS: | 959551-10-1 | | MF: | C20H14F3N3S | | MW: | 385.41 | | EINECS: | | | Product Categories: | | | Mol File: | 959551-10-1.mol |  |
| | NIH-12848 Chemical Properties |
| Boiling point | 441.6±45.0 °C(Predicted) | | density | 1.384±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 25 mg/mL | | form | A crystalline solid | | pka | 5.05±0.30(Predicted) |
| | NIH-12848 Usage And Synthesis |
| Uses | NIH-12848 is a a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor, and also a potentially powerful tool for exploring the cell physiology of PI5P4Ks. Reagent in the synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amines as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. |
| | NIH-12848 Preparation Products And Raw materials |
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