- ARS-1620
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- $1.00 / 1KG
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2020-01-19
- CAS:1698055-85-4
- Min. Order: 1KG
- Purity: 99.0%
- Supply Ability: 100kg
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| | ARS-1620 Basic information |
| Product Name: | ARS-1620 | | Synonyms: | ARS-1620;CPD1588;ARS-1620;ARS 1620;ARS1620;(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one;1-?[4-?[(7S)?-?6-?Chloro-?8-?fluoro-?7-?(2-?fluoro-?6-?hydroxyphenyl)?-?4-?quinazolinyl]?-?1-?piperazinyl]?-?2-?propen-?1-?one;2-Propen-1-one, 1-[4-[(7S)-6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-;(S)-1-[4-[6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one;inhibit,Ras,Inhibitor,ARS-1620,ARS 1620,ARS1620 | | CAS: | 1698055-85-4 | | MF: | C21H17ClF2N4O2 | | MW: | 430.84 | | EINECS: | | | Product Categories: | APIs;API | | Mol File: | 1698055-85-4.mol |  |
| | ARS-1620 Chemical Properties |
| Boiling point | 614.7±55.0 °C(Predicted) | | density | 1.434±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:70.0(Max Conc. mg/mL);162.47(Max Conc. mM) | | form | A solid | | pka | 6.03±0.35(Predicted) |
| | ARS-1620 Usage And Synthesis |
| Uses | ARS-1620, is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics. | | Definition | ChEBI: ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an inhibitor, an antiviral agent and an antineoplastic agent. |
| | ARS-1620 Preparation Products And Raw materials |
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