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| | Propionyl-L-carnitine hydrochloride Basic information |
| | Propionyl-L-carnitine hydrochloride Chemical Properties |
| Melting point | 165-167°C | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Chloroform (Slightly), Water (Slightly) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | CAS DataBase Reference | 119793-66-7(CAS DataBase Reference) |
| | Propionyl-L-carnitine hydrochloride Usage And Synthesis |
| Description | Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids. Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; ) and 6-keto-prostaglandin F1α in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; ) in non-contaminated cells. It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal. Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia. | | Chemical Properties | White Solid | | Uses | L-Propionyl carnitine has been shown to improve the heart's mechanical recovery and other metabolic parameters after ischemia-reperfusion. | | Uses | L-Propionyl carnitine has been shown to improve the heart''s mechanical recovery and other metabolic parameters after ischemia-reperfusion. | | Uses | antihypertensive | | Brand name | Dromos (Biosint S.p.A.). | | storage | +4°C |
| | Propionyl-L-carnitine hydrochloride Preparation Products And Raw materials |
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