| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:~2.0 mg/mL, clone NF1-4, purified immunoglobulin Remarks:clone 2D1, purified immunoglobulin, buffered aqueous solution
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| Company Name: |
AUSTRAL Biologicals
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| Tel: |
925 543 0018 |
| Email: |
sales@australbiologicals.com |
| Products Intro: |
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| | ANTI-TFYY1 (NF1) Basic information |
| Product Name: | ANTI-TFYY1 (NF1) | | Synonyms: | ANTI-TFYY1 (NF1);Anti-DKFZp686J1293;Anti-neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease);Anti-NFNS;Anti-VRNF;Anti-WSS;Monoclonal Anti-NF1 antibody produced in mouse;Anti-NF1 antibody produced in rabbit | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-TFYY1 (NF1) Structure]() |
| | ANTI-TFYY1 (NF1) Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution |
| | ANTI-TFYY1 (NF1) Usage And Synthesis |
| Uses | Monoclonal Anti-NF1 antibody produced in mouse has been used in western blotting. It may be suitable for use in flow cytometry. | | General Description | Monoclonal Anti-NF1 (mouse IgM isotype) is derived from the hybridoma NF1-333 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Neurofibromin 1 (NF1) gene is located at chromosome 17q11.2. It is predominantly expressed in neurons, Schwann cells, oligodendrocytes, astrocytes and leukocytes. NF1 has two potentially functional domains; Ras GTPase activating protein (RasGAP)and phosphatidylinositol-transfer protein. | | Biochem/physiol Actions | NF1 acts as a negative regulator of the p21-Ras/mitogen-activated protein kinase (MAPK) pathway as well as a tumor suppressor gene. Mutations in the neurofibromin 1 (NF1) gene is implicated in Neurofibromatosis type 1 (NF1) gene also known as von Recklinghausen peripheral or classical neurofibromatosis, is one of the most common autosomal dominant diseases. Consistent with a central role for neurofibromin in cellular function, recent cancer genome sequencing studies have found that somatic NF1 gene mutations occur not only in association with NF1, but also in a number of other common cancers. A variety of benign and malignant tumours are associated with NF1 and all involve tumorigenesis of neural crest-derived cells. |
| | ANTI-TFYY1 (NF1) Preparation Products And Raw materials |
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