| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:ICRF-193
CAS:21416-88-6
Purity:>=95% Package:1mg, 5mg Remarks:I4659
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:ICRF-193
CAS:21416-88-6
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing1@energy-chemical.com |
| Products Intro: |
Product Name:ICRF-193 apoptosis inducer, arabinosidase substrate
CAS:21416-88-6
Purity:NULL Package:1mg;5mg Remarks:NULL
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| | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Basic information |
| Product Name: | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT | | Synonyms: | 2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, (R*,S*)-;2,6-Piperazinedione, 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-, rel-;2,6-Piperazinedione, 4,4'-(1,2-dimethylethylene)di-, meso-;Brn 3981691;meso-2,3-Bis(3,5-dioxopiperazin-1-yl)butane;meso-2,3-Bis(3,5-dioxopiperazine-1-yl)butane;2,6-Piperazinedione, 4,4'-[(1R,2S)-1,2-dimethyl-1,2-ethanediyl]bis-, rel-;ICRF-193 apoptosis inducer, arabinosidase substrate | | CAS: | 21416-88-6 | | MF: | C12H18N4O4 | | MW: | 282.3 | | EINECS: | | | Product Categories: | | | Mol File: | 21416-88-6.mol |  |
| | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Chemical Properties |
| density | 1.308 | | storage temp. | -20°C | | solubility | DMSO: soluble4mg/mL |
| Hazard Codes | Xn | | Risk Statements | 22-43 | | Safety Statements | 36/37 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | TL6380200 |
| | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Usage And Synthesis |
| Uses | ICRF-193 has been used as a topoisomerase II (TOP2) inhibitor to treat mouse oocytes to investigate the role of TOP2 in meiosis. | | Definition | ChEBI: ICRF-193 is an N-alkylpiperazine that is butane which is substituted by a 3,5-dioxopiperazin-1-yl group at positions 2 and 3. The meso isomer. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an apoptosis inducer and an antineoplastic agent. | | General Description | ICRF-193 is a bisdiopiperazine derivative. It inhibits topoisomerase II by forming a non-cleavable?complex. | | Biochem/physiol Actions | ICRF-193 induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation. Induces apoptosis in several cell lines including K562 and Molt-4 cells., ICRF-193 is a topoisomerase II inhibitor, more potent against topoisomerase II-β than topoisomerase II-α, and may in addition cause DNA strand breaks. |
| | HEPARIN, SODIUM, LOW MOLECULAR WEIGHT Preparation Products And Raw materials |
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