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| | HYDROXYFASUDIL MONOHYDROCHLORIDE Basic information |
| | HYDROXYFASUDIL MONOHYDROCHLORIDE Chemical Properties |
| Melting point | >250 (dec.) | | storage temp. | Inert atmosphere,2-8°C | | solubility | H2O: >5mg/mL | | form | solid | | color | white | | Water Solubility | Soluble in water (20mM) | | InChIKey | XWWFOUVDVJGNNG-UHFFFAOYSA-N |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | HYDROXYFASUDIL MONOHYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | Off-White Solid | | Uses | A metabolite of Fasudil. A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties. Reported to inhibit the Rho kinase-mediated (ROCK) contraction both in vitro and in vivo. | | General Description | A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 μM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo. | | Biochem/physiol Actions | Cell permeable: yes | | storage | -20°C |
| | HYDROXYFASUDIL MONOHYDROCHLORIDE Preparation Products And Raw materials |
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