Lactimidomycin
| 中文名称 | Lactimidomycin |
|---|---|
| 中文同义词 | 化合物 T15703;4-[(Z)-2-羟基-5-甲基-7-[(4Z,6Z,10Z)-3-甲基-12-氧代-1-氧杂环十二碳-4,6,10-三烯-2-基]-4-氧代辛-6-烯基]哌啶-2,6-二酮 |
| 英文名称 | Lactimidomycin |
| 英文同义词 | Lactimidomycin;Lactimidomycin (Bu-4146T);4-[(Z)-2-hydroxy-5-methyl-7-[(4Z,6Z,10Z)-3-methyl-12-oxo-1-oxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-enyl]piperidine-2,6-dione;2,6-Piperidinedione, 4-[(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4Z,6E,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxo-6-octen-1-yl]- |
| CAS号 | 134869-15-1 |
| 分子式 | C26H35NO6 |
| 分子量 | 457.56 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 134869-15-1.mol |
| 结构式 |  |
Lactimidomycin 性质
| 储存条件 | Store at -20°C |
|---|
Eukaryotic translation elongation
Dengue virus 2 and other RNA viruses
Lactimidomycin (0.01-100 nM; 24 hours; Hs 579T, HCC 1937, HCC 1395, HCC 2218, BT 474, MCF 7, MDA MB231 cells and MCF 10A) treatment inhibits cell growth with IC
50
concentrations in the low nanomolar range, but higher doses are necessary to inhibit growth of the non-tumorigenic breast cell line MCF10A.
Lactimidomycin induces a clear dose-responsive inhibition of DENV2 infectious particle production with an EC
90
value of 0.4 μM. No measurable decrease in cell viability was detected at concentrations up to 12.5 µM.
Lactimidomycin is a potent inhibitor of DENV2 and Lactimidomycin's inhibition of DENV2 translation leads to reduced production of newly infectious particles. Lactimidomycin may protect cells from viral cytopathic effects including apoptosis, likely through inhibition of virus protein production and replication.
Cell Proliferation Assay
| Cell Line: | Hs 579T, HCC 1937, HCC 1395, HCC 2218, BT 474, MCF 7, MDA MB231 cells and MCF 10A |
| Concentration: | 0.01-100 nM |
| Incubation Time: | 24 hours |
| Result: | Inhibited cell growth with IC 50 concentrations in the low nanomolar range. |
Lactimidomycin (0.6 mg/kg; intraperitoneal injection; daily; for one month; female nude mice) treatment has an appreciable effect on tumor growth in nude mice.
| Animal Model: | Female nude mice (6-8 week old) with MDA MB 231 cells |
| Dosage: | 0.6 mg/kg |
| Administration: | Intraperitoneal injection; daily; for one month |
| Result: | Had an appreciable effect on tumor growth in vivo. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-18979 | Lactimidomycin Lactimidomycin | 134869-15-1 | 200μg | 9700元 |