| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:ER-000444793
CAS:792957-74-5
Purity:150RMB/1mg Package:>98%
|
|
| | ER-000444793 Basic information |
| Product Name: | ER-000444793 | | Synonyms: | ER-000444793;ER-000444793
(ER000444793);4-Quinolinecarboxamide, 1,2-dihydro-2-oxo-N-[2-(phenylmethyl)phenyl]-;N-(2-Benzylphenyl)-2-oxo-1,2-dihydroquinoline-4-carboxamide;Mitochondrial Metabolism,Inhibitor,ER-000444793,inhibit,ER000444793,ER 000444793 | | CAS: | 792957-74-5 | | MF: | C23H18N2O2 | | MW: | 354.4 | | EINECS: | | | Product Categories: | | | Mol File: | 792957-74-5.mol |  |
| | ER-000444793 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : ≥ 100 mg/mL (282.17 mM) |
| | ER-000444793 Usage And Synthesis |
| Biological Activity | ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening. It inhibits mPTP with IC50 of 2.8 μM. | | in vitro | ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. It potently and dose-dependently inhibits Ca 2+ -induced mPT. It binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC 50 =23 nM and SfA IC 50 = 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled -CsA from rhCypD protein. Together, these data suggest the mechanism of it in delaying mPT is independent of CypD functional inhibition. | | target | |
| | ER-000444793 Preparation Products And Raw materials |
|