- Cilofexor
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- $9.80 / 1KG
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2020-01-03
- CAS:1418274-28-8
- Min. Order: 1KG
- Purity: 97%-99%
- Supply Ability: 1kg -1000kg
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| | Cilofexor Basic information |
| Product Name: | Cilofexor | | Synonyms: | Cilofexor;Cilofexor （GS-9674);2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)isonicotinic acid;GS-9674;GS9674;CILOFEXOR;CS-2761;2-[3-(2-chloro-4-{[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy}phenyl)-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid;4-Pyridinecarboxylic acid, 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]phenyl]-3-hydroxy-1-azetidinyl]-;GS9674,Inhibitor,inhibit,NR1H4,FXR,Cilofexor,PSC,GS 9674,oral,NASH,GS-9674,antifibrotic,nonsteroidal,anti-inflammatory,Autophagy,safety | | CAS: | 1418274-28-8 | | MF: | C28H22Cl3N3O5 | | MW: | 586.85 | | EINECS: | | | Product Categories: | API | | Mol File: | 1418274-28-8.mol |  |
| | Cilofexor Chemical Properties |
| Boiling point | 855.5±65.0 °C(Predicted) | | density | 1.538±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:32.5(Max Conc. mg/mL);55.38(Max Conc. mM) | | form | A crystalline solid | | pka | 2.10±0.10(Predicted) |
| | Cilofexor Usage And Synthesis |
| Description | Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay). It has FXR agonist activity in a mammalian one hybrid (M1H) assay (EC50 = ≥100 nM). |
| | Cilofexor Preparation Products And Raw materials |
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