LM 22A4
| 中文名称 | LM 22A4 |
|---|---|
| 中文同义词 | N,N',N''-三(2-羟基乙基)-1,3,5-苯三甲酰胺;均苯三甲酰乙醇胺;化合物LM22A-4;LM22A-4,神经营养性BDNF模拟物 |
| 英文名称 | LM 22A4 |
| 英文同义词 | LM 22A4;N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide;N,N',N''-Tris(beta-hydroxyethyl)trimesamide;1-N,3-N,5-N-TRIS(2-HYDROXYETHYL)BENZENE-1,3,5-TRICARBOXAMIDE;BD2-4;LM 22A4; LM 22A-4;1,3,5-Benzenetricarboxamide, N1,N3,N5-tris(2-hydroxyethyl)-;LM-22A-4,Inhibitor,Trk Receptor,inhibit,LM22A4,LM22A-4,Tropomyosin related kinase receptor,LM22A 4 |
| CAS号 | 37988-18-4 |
| 分子式 | C15H21N3O6 |
| 分子量 | 339.34 |
| EINECS号 | |
| 相关类别 | Agonist, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals |
| Mol文件 | 37988-18-4.mol |
| 结构式 |  |
LM 22A4 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 在水中的溶解度为性2mg/mL，澄清（加热） |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 或蒸馏水中的溶液可在 -20° 下储存长达 1 个月。 |
| Target | Value |
|
TrkB
() |
LM22A-4 significantly up-regulates OPN and ALPase mRNA expression in a dose-dependent manner and OC mRNA level is significantly increased by 5 μM of LM22A-4. LM22A-4 significantly increases OPN, ALPase and OC mRNA expression in a time-dependent manner. LM22A-4 stimulated OPN and OC mRNA expression in HCEM cells cultured with mineralizing media.
LM22A-4 (10 mg/kg, i.p.) significantly reduces the degree of tissue injury and apoptosis (TUNEL staining and caspase-3 and Bcl-2 expression) compared with vehicle treated group. LM22A-4 also significantly ameliorates the recovery of limb function. LM22A-4 (10 mg/kg) treatment results in a significant increase in neuron number. LM22A-4 administration (10 mg/kg) significantly improves the neurological scores compared with those of the solvent-treated animals.
安全信息
| WGK Germany | 3 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-100673 | LM22A-4 | 1 mg | 240元 | |
| 2024/04/30 | HY-100673 | LM 22A4 LM22A-4 | 37988-18-4 | 5mg | 600元 |