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TargetMol Chemicals Inc.
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021-021-33632979 15002134094 |
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| Products Intro: |
Product Name:CNQX disodium
CAS:479347-85-8
Package:1 mg;10 mg;25 mg;5 mg Remarks: 90+%，具体纯度信息请见官网
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| | CNQX disodium salt Basic information |
| Product Name: | CNQX disodium salt | | Synonyms: | 3-dione disodium;6-Cyano-7-nitroquinoxaline-2;7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile, disodium salt | | CAS: | 479347-85-8 | | MF: | C9H5N4NaO4 | | MW: | 256.15 | | EINECS: | | | Product Categories: | | | Mol File: | 479347-85-8.mol |  |
| | CNQX disodium salt Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | ≥27.6 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O | | form | solid | | color | Brown or yellow | | Water Solubility | Soluble to 20 mM in water |
| | CNQX disodium salt Usage And Synthesis |
| Uses | CNQX Disodium Salt (cas# 479347-85-8) is a useful research chemical.CNQX Disodium Salt was used in the study of compositions and methods for treating neurological disorders or damage. | | Biological Activity | cnqx disodium salt is an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) and kainate receptors, with ic50 values of 0.3 and 1.5 μm, respectively [1].ampa and kainate receptors, collectively referred to as non-n-methyl-d-aspartate receptors, are distinct receptor complexes, but activated by the same agonists. ampa and kainate receptors are involved in rapidly desensitizing responses in central nervous system [2].in thalamic reticular nucleus neurons, cnqx (20 μm) depolarized all cells tested in a similar manner as dnqx. with longer cnqx application (5 min vs. 1 min), the depolarization persisted throughout cnqx application. however, in ventrobasal neurons, cnqx (20 μm) produced negligible effects on the membrane potential [3].in sprague-dawley rats, pretreatment with cnqx (0.02, 0.1, 0.6, 3 and 15 mg/kg), administered intraperitoneally 15 min before capsaicin, significantly reduced c-fos-labelled cells within trigeminal nucleus caudalis by a maximum of 45%. the number of c-fos-like immunoreactivity cells within lateral reticular, medullary reticular, and solitary tract nuclei was not affected [4].[1]. honoré t, davies s n, drejer j, et al. quinoxalinediones: potent competitive non-nmda glutamate receptor antagonists. science, 1988, 241(4866): 701-703.[2]. bettler b, mulle c. ampa and kainate receptors. neuropharmacology, 1995, 34(2): 123-139.[3]. lee s h, govindaiah g, cox c l. selective excitatory actions of dnqx and cnqx in rat thalamic neurons. journal of neurophysiology, 2010, 103(4): 1728-1734.[4]. mitsikostas d d, sanchez del rio m, waeber c, et al. non-nmda glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis. british journal of pharmacology, 1999, 127(3): 623-630. | | storage | Room temperature (desiccate) |
| | CNQX disodium salt Preparation Products And Raw materials |
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