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| Product Name: | K-252C | | Synonyms: | K-252C;STAUROSPORINE AGLYCONE;Staurosporinone;6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one;Staurosporine Aglycone >99%;Staurosporinone, K-252c;K-252c(Staurosporinone);K252c / Staurosporine Aglycone>99%/ Staurosporinone, K-252C /
6,7,12,13-Tetrahydro-5H-Indolo[2,3-A]Pyrrolo[3,4-C]Carbazol-5-One | | CAS: | 85753-43-1 | | MF: | C20H13N3O | | MW: | 311.34 | | EINECS: | | | Product Categories: | Inhibitor | | Mol File: | 85753-43-1.mol |  |
| | K-252C Chemical Properties |
| Melting point | >200°C (dec.) | | storage temp. | −20°C | | solubility | DMSO: 10 mg/mL, soluble | | form | solid | | color | Pale Brown to Light Brown | | Water Solubility | Soluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water. |
| Safety Statements | 22-24/25 | | RIDADR | NA 1993 / PGIII | | WGK Germany | 3 | | HS Code | 29333990 |
| | K-252C Usage And Synthesis |
| Uses | Inhibits protein kinase C | | Biological Activity | Inhibitor of protein kinase C (IC 50 = 2.45 μ M) that displays ~ 10-fold selectivity over protein kinase A (IC 50 = 25.7 μ M). Also inhibits β -lactamase, malate dehydrogenase and chymotrypsin (IC 50 values are 8, 8 and 10 μ M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC 50 values range from 0.13-0.32 μ M). Shows no activity against herpes simplex virus (HSV). | | storage | -20°C | | references | 1. fabre s, prudhomme m, rapp m. protein kinase c inhibitors; structure-activity relationships in k252c-related compounds. bioorg med chem 1993,1:193-196.2. hashimoto s. k-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in pc12h cells. j cell biol 1988,107:1531-1539.3. raychaudhuri sp, sanyal m, weltman h, kundu-raychaudhuri s. k252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. j invest dermatol 2004,122:812-819. |
| | K-252C Preparation Products And Raw materials |
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