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| | FOLIC ACID DIHYDRATE Basic information |
| Product Name: | FOLIC ACID DIHYDRATE | | Synonyms: | PTEROYLGLUTAMIC ACID DIHYDRATE;PTEROYLGLUTAMIC ACID;PGA DIHYDRATE;FOLIC ACID, 500MG, NEAT;FOLIC ACID DIHYDRATE 97%;FolicAcidB.P.;L-Glutamic acid, N-4-(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methylaminobenzoyl-, dihydrate;FOLIC ACID pure | | CAS: | 75708-92-8 | | MF: | C19H23N7O8 | | MW: | 477.43 | | EINECS: | 200-419-0 | | Product Categories: | | | Mol File: | 75708-92-8.mol |  |
| | FOLIC ACID DIHYDRATE Chemical Properties |
| Melting point | 250°C | | storage temp. | Store at RT. | | solubility | Aqueous Acid (Slightly), Aqueous Base (Slightly), DMSO (Slightly) | | pka | pK1:8.26 (25°C) | | form | Solid | | color | Yellow to Dark Yellow | | Water Solubility | Miscible with water. | | Merck | 14,4221 | | BRN | 100781 | | CAS DataBase Reference | 75708-92-8 |
| WGK Germany | 3 | | RTECS | LP5425000 | | TSCA | Yes |
| | FOLIC ACID DIHYDRATE Usage And Synthesis |
| Chemical Properties | Yellow to yellow-orange crystalline powd | | Uses | Vitamin B9. A B-complex vitamin necessary for the body to produce red blood cellsFolic acid dehydrate is used to form non-covalent complexes with polyethylenimine. It is used for the delivery of genes, which finds application in gene therapy. It is a B-complex vitamin, which is necessary for the body to produce red blood cells. | | Purification Methods | If paper chromatography indicates impurities, then recrystallise it from hot H2O or from dilute acid [Walker et al. J Am Chem Soc 70 19 1948]. Impurities may be removed by repeated extraction with n-BuOH of a neutral aqueous solution of folic acid (by suspending in H2O and adding N NaOH dropwise till the solid dissolves, then adjusting the pH to ~7.0-7.5) followed by precipitation with acid, filtration, or better collected by centrifugation and recrystallised form hot H2O. [Blakley Biochem J 65 331 1975, Kalifa et al. Helv Chim Acta 6 1 2739 1978.] Chromatography on cellulose followed by filtration through charcoal has also been used to obtain pure acid. [Sakami & Knowles Science 129 274 1959.] UV: max 247 and 296nm ( 12,800 and 18,700) in H2O pH 1.0; 282 and 346nm ( 27.600 and 7,200) in H2O pH 7.0; 256, 284 and 366nm ( 24600, 24,500 and 86,00) in H2O pH 13 [Rabinowitz in The Enzymes (Boyer et al. Eds), 2 185 1960]. [Beilstein 26 III/IV 3944.] |
| | FOLIC ACID DIHYDRATE Preparation Products And Raw materials |
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