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ShangHai Biochempartner Co.,Ltd
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| Products Intro: |
Product Name:GNE-8324
CAS:1698901-76-6
Purity:98% HPLC LCMS Package:500mg;1g;10g
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| | GNE-8324 Basic information |
| Product Name: | GNE-8324 | | Synonyms: | GNE 8324;GNE8324;GNE-8324;GNE-8324; GNE 8324; GNE8324;4H,6H-Cyclopenta[4,5]thiazolo[3,2-a]pyrimidin-4-one, 2-[[ethyl(4-fluorophenyl)amino]methyl]-7,8-dihydro- | | CAS: | 1698901-76-6 | | MF: | C18H18FN3OS | | MW: | 343.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1698901-76-6.mol |  |
| | GNE-8324 Chemical Properties |
| | GNE-8324 Usage And Synthesis |
| Description | GNE-8324 is a potent and selective NMDA receptor PAM. | | in vitro | This study showed previously that NMDAR positive allosteric modulator GNE-8324 and M-8324 selectively increase NMDAR activity on the inhibitory neurons and elevates their activity in vitro and in vivo._x000D_
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Reference: Front Pharmacol. 2022 Jan 4;12:796179. https://pubmed.ncbi.nlm.nih.gov/35058780/ | | target | GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons. |
| | GNE-8324 Preparation Products And Raw materials |
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