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| | (S)-3-PHENYLBUTYRIC ACID Basic information |
| Product Name: | (S)-3-PHENYLBUTYRIC ACID | | Synonyms: | (s)-β-methylhydrocinnamic acid;(3S)-3-Phenylbutanoic acid;(3S)-3-Phenylbutyric acid;(S)-3-Phenylbutanoic acid;(2S)-2-Methyl-3-phenylpropanoic acid;(S)-3-Phenylisobutyric acid;(S)-α-Methylbenzenepropionic acid;[S,(+)]-2-Benzylpropionic acid | | CAS: | 772-15-6 | | MF: | C10H12O2 | | MW: | 164.2 | | EINECS: | | | Product Categories: | | | Mol File: | 772-15-6.mol |  |
| | (S)-3-PHENYLBUTYRIC ACID Chemical Properties |
| Boiling point | 94-95 °C0.3 mm Hg(lit.) | | density | 1.069 g/mL at 20 °C(lit.) | | refractive index | n20/D 1.518 | | pka | 4.67±0.10(Predicted) |
| | (S)-3-PHENYLBUTYRIC ACID Usage And Synthesis |
| Chemical Properties | optical purity >99% | | Uses | (S)-3-Phenylbutyric Acid is used as a sole carbon and energy source in the isolation of Rhodococcus rhodochrous PB1 from compost soil.Also, it is used in the design and synthesis of 2-Acylaminopyridin-4-ylimidazoles as p38 MAP kinase inhibitors in the treatment of many inflammatory disorders. | | Purification Methods | Purify the acids as the 2-isomer above, i.e. by distillation, but under a good vacuum. [Prelog & Scherrer Helv Chim Acta 42 2227 1959, Levene & Marker J Biol Chem 93 761 1932, 100 685 1933, Cram J Am Chem Soc 74 2137 1952.] The R-amide crystallises from H2O, with m 101.5-102o, and [] 20 -16.5o (c 1.2, EtOH). The racemic acid has m 39-40o, b 134-136o/6mm, 158o/12mm [Marvel et al. J Am Chem Soc 62 3499 1940]. [Beilstein 9 IV 1813.] |
| | (S)-3-PHENYLBUTYRIC ACID Preparation Products And Raw materials |
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