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| | Thioproperazine Basic information |
| Product Name: | Thioproperazine | | Synonyms: | thioproperazine;N,N-Dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide;10H-Phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-;Cephalmin;Phenothiazine-2-sulfonamide, N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-;Sulfenazin;N'-(4-chlorophenyl)-N,N-dimethylcarbamimidic acid methyl ester;hioproperazine | | CAS: | 316-81-4 | | MF: | C22H30N4O2S2 | | MW: | 446.63 | | EINECS: | 2062624 | | Product Categories: | | | Mol File: | 316-81-4.mol |  |
| | Thioproperazine Chemical Properties |
| Melting point | 140° | | Boiling point | 612.2±65.0 °C(Predicted) | | density | 1.1476 (rough estimate) | | refractive index | 1.6200 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | pka | 7.65±0.10(Predicted) | | NIST Chemistry Reference | Thioproperazine(316-81-4) |
| Toxicity | LD50 oral in mouse: 830mg/kg |
| | Thioproperazine Usage And Synthesis |
| Originator | Majeptil,Specia,France,1960 | | Definition | ChEBI: A phenothiazine derivative in which the phenothiazine tricycle has a dimethylaminosulfonyl substituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at N-10. | | Manufacturing Process | A solution of 3-dimethylsulfamoylphenthiazine (5 g) in anhydrous xylene (100
cc) is heated under reflux for 1 hour with sodamide (0.67 g). 3-(4-methyl-1-
piperazinyl)-1-chloropropane (3.2 g) in solution in anhydrous xylene (20 cc) is
added and the mixture heated under reflux for 5 hours. After treatment of the
reaction products, a crude oily base (2.5 g) is obtained after treatment. By
the addition of a solution of fumaric acid in ethanol to an ethanolic solution of
the base, 3-dimethylsulfamoyl-10-(3-41-methyl-11-piperazinylpropyl)-
phenthiazinediacid fumarate (2.6 g) is obtained, melting point 182°C. The
base recrystallized from ethyl acetate melts at about 140°C. | | Therapeutic Function | Neuroleptic, Antiemetic |
| | Thioproperazine Preparation Products And Raw materials |
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