Company Name: |
J & K SCIENTIFIC LTD.
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Tel: |
010-82848833 400-666-7788 |
Email: |
jkinfo@jkchemical.com |
Products Intro: |
Product Name:Thioridazine 2-Sulfone CAS:14759-06-9 Package:50Mg,5Mg
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Company Name: |
ChemStrong Scientific Co.,Ltd
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Tel: |
0755-0755-66853366 13670046396 |
Email: |
sales@chem-strong.com |
Products Intro: |
Product Name:Thioridazine EP Impurity E CAS:14759-06-9 Purity:95% HPLC Package:10mg;25mg;50mg;100mg
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| sulforidazine Basic information |
| sulforidazine Chemical Properties |
Melting point | 121-123° | Boiling point | 589.1±50.0 °C(Predicted) | density | 1?+-.0.06 g/cm3(Predicted) | storage temp. | Refrigerator, Under Inert Atmosphere | solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) | form | Solid | pka | 9.83±0.10(Predicted) | color | Off-White to Dark Yellow |
| sulforidazine Usage And Synthesis |
Chemical Properties | Thick Yellow Oil | Originator | Sulforidazine,ZYF Pharm Chemical | Uses | Thioridazine 2-Sulfone (Thioridazine EP Impurity E) is a major metabolite of Thioridazine (THD 2-SO2). | Definition | ChEBI: Sulforidazine is a member of phenothiazines. | Manufacturing Process | A mixture of 96.5 g 2-methylsulfonylphenothiazine, 50 g 2-(2-chloroethyl)-1-
methylpiperidine, 62 g diethyl carbonate and 2 g sodium methylate was
heated at 135°C for 1 hour and then at 180-190°C for 2.5 hours. The product
was dissolved in benzene (500 ml) and the solution was extracted with 700 ml
of 15% aqueous solution tartaric acid. The extract was washed with benzene.
After addition of sodium carbonate solution to the extract was obtained a
precipitate which was dissolved in benzene. This solution was washed with
water and concentrated. 2-Methylsulfonyl-10-(2-(1-methyl-2-
piperidyl)ethyl)phenothiazin was recrystallized from acetone, melting point
121-123°C. | Therapeutic Function | Neuroleptic |
| sulforidazine Preparation Products And Raw materials |
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