| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
400-400-6206333 18521732826 |
| Email: |
market@aladdin-e.com |
| Products Intro: |
Product Name:Zinterol hydrochloride
CAS:38241-28-0
Purity:98% (HPLC) Package:5mg/RMB 1312.90
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| Company Name: |
BOC Sciences
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| Tel: |
|
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Zinterol hydrochloride
CAS:38241-28-0
Purity:≥98% by HPLC Remarks:Zinterol hydrochloride is a potent and selective β2-adrenoceptor agonist (pKB = 8.3 and < 5.7 for β 2 and β1 receptors respectively, as measured in human artery).
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:Zinterol hydrochloride >=98% (HPLC)
CAS:38241-28-0
Purity:98% (HPLC) Package:25mg;5mg Remarks:NULL
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| | Zinterol hydrochloride Basic information |
| Product Name: | Zinterol hydrochloride | | Synonyms: | MJ-9184-1;Zinterol hydrochloride;N-[5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-Methanesulfonamide Hydrochloride;Zinterol HCl;Zinterol hydrochloride >=98% (HPLC) | | CAS: | 38241-28-0 | | MF: | C19H27ClN2O4S | | MW: | 414.94668 | | EINECS: | | | Product Categories: | | | Mol File: | 38241-28-0.mol |  |
| | Zinterol hydrochloride Chemical Properties |
| storage temp. | room temp | | solubility | DMSO: ≥15mg/mL | | form | powder |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26 | | WGK Germany | 3 |
| | Zinterol hydrochloride Usage And Synthesis |
| Originator | Zinterol
Hydrochloride,ZYF Pharm
Chemical | | Uses | Bronchodilator. | | Uses | Zinterol Hydrochloride is an acidic salt of Zinterol (Z460000). Zinterol is a β2-adrenergic agonist. It can be used to induce smooth muscle relaxation in the lungs, gastrointestinal tract, uterus, and various blood vessels. | | Manufacturing Process | A). 2'-Hydroxy-5'-([N-(2-methyl-1-phenyl-2-propyl)glycyl]methane-
sulfonanilide hydrobromide:
To a solution of α,α-dimethylphenthylamine (120 g, 0.8 mole) in 1.1 liter of
acetonitrile is added 5'-bromoacetyl-2'-hydroxymethanesulfonanilide (108 g,
0.35 mole) in a period of 5 minutes. The resulting solution is refluxed for 5
minutes on a steam bath and then permitted to stand for 25 minutes at room
temperature after which it is chilled and acidified with 5 N ethanolic hydrogen
bromide. The acidified mixture is concentrated in vacuum until a thick slurry is
obtained. After standing overnight at room temperature, the slurry is filtered
and the crude product triturated with 2-butanone, filtered, washed with 2-
butanone and dried to 86.3 g, (54%), MP: 217.5-221°C (dec.).
B). 2'-Hydroxy-5'-(1-hydroxy-2-(2-methyl-1-phenyl-2-propylamino)ethyl)
methanesulfonanilide hydrobromide:
2'-Hydroxy-5'-([N-(2-methyl-1-phenyl-2-propyl)glycyl]methanesulfonanilide
hydrobromide (132 g, 0.29 mole is dissolved in 2 liters of hot methanol, the
methanolic solution is allowed to cool to room temperature and 13 g 10%
palladium on carbon catalyst suspended in 50 ml of water is added.
Hydrogenation of the stirred mixture is carried out under 1-3 atm. of pressure
for 17 hours during which time 0.31 mole of hydrogen is absorbed. The
catalyst is filtered and the filtrate concentrated under reduced pressure until a
thick slurry is obtained. Isoptopanpl is added tothed slurry and the mixture is
again concentrated in vacuum to remove water by azeotropic distillation.
Trituration of residual solid with 2-propanol and collection on a filter affords
100.5 g (76% yield) of desired product, MP: 194.5-195.5°C (dec.).
2'-Hydroxy-5'-(1-hydroxy-2-(2-methyl-1-phenyl-2-propylamino)ethyl)
methanesulfonanilide base:
2'-Hydroxy-5'-(1-hydroxy-2-(2-methyl-1-phenyl-2-propylamino)ethyl)
methanesulfonanilide hydrobromide (47.7 g) is refluxed with 100 ml of
methanol. The material only partly dissolves. A solution of 6.5 g of potassium
hydroxide in 25 ml of methanol is then added to the suspension followed by 1
L of water. The mixture is thoroughly stirred and cooled to 5-10°C. The
precipitate is collected on a filter and washed with water until a negative test
for bromide using silver nitrate is obtained. The product is dried in an oven at
65°C, yield 36 g. | | Therapeutic Function | Bronchodilator | | storage | Store at +4°C |
| | Zinterol hydrochloride Preparation Products And Raw materials |
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