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| | 1H-1-Ethyl Candesartan Cilexetil Basic information |
| Product Name: | 1H-1-Ethyl Candesartan Cilexetil | | Synonyms: | 1H-1-Ethyl Candesartan Cilexetil;2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;2-Ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-;Candesartan Cilexetil EP IMpurity E;Candesartan Cilexetil EP Impurity EQ: What is
Candesartan Cilexetil EP Impurity E Q: What is the CAS Number of
Candesartan Cilexetil EP Impurity E Q: What is the storage condition of
Candesartan Cilexetil EP Impurity E Q: What are the applications of
Candesartan Cilexetil EP Impurity E;Candesartan Cilexetil EP Impurity E (Candesartan Cilexetil N1-Ethyl Analog);1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(1-ethyltetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate | | CAS: | 914613-35-7 | | MF: | C35H38N6O6 | | MW: | 638.71282 | | EINECS: | | | Product Categories: | Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 914613-35-7.mol |  |
| | 1H-1-Ethyl Candesartan Cilexetil Chemical Properties |
| Melting point | 90-93°C | | Boiling point | 842.0±75.0 °C(Predicted) | | density | 1.32 | | storage temp. | Refrigerator | | solubility | ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 3.95±0.10(Predicted) |
| | 1H-1-Ethyl Candesartan Cilexetil Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | Candesartan Cilexetil Impurity E (PHARMEUROPA). | | Biological Activity | 1h-1-ethyl candesartan cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin ii type 1 receptor (at1) antagonist.angiotensin ii is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including at1[1]. at1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. furthermore, at1 mediates the classical biological actions of angiotensin ii. also, at1 has seven helical transmembrane domains, which is the characteristic of the superfamily of g-protein-coupled receptors. carboxyl-terminal region structure of at1 plays important roles in receptor internalization, desensitization and phosphorylation [2]. | | references | [1]. otsuka, m. reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin ii type 1 receptor antagonist. thorax. 2004; 59(1): 31-38.
[2]. guo, d., sun, y., hamet, p., & inagami, t. the angiotensin ii type 1 receptor and receptor-associated proteins. cell research. 2001; 11(3): 165-180. |
| | 1H-1-Ethyl Candesartan Cilexetil Preparation Products And Raw materials |
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