tert-butyl (2-bromo-6-fluorophenyl)carbamate

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Products Intro: Product Name:tert-butyl N-(2-bromo-6-fluorophenyl)carbamate
CAS:1057720-25-8
Purity:95+% Package:100mg;250mg;500mg;1g;2.5g;5g;10g
Company Name: Xi'an Zhenghao Biotechnology Co., Ltd  
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Products Intro: Product Name:tert-butyl (2-bromo-6-fluorophenyl)carbamate
CAS:1057720-25-8
Purity:95% Package:1G;5G;10G~500G;1KG;10KG;
Company Name: Shanghai Haohong Pharmaceutical Co., Ltd.  
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Products Intro: Product Name:tert-Butyl (2-bromo-6-fluorophenyl)carbamate
CAS:1057720-25-8
Purity:95%
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Products Intro: Product Name:Tert-Butyl(2-Bromo-6-Fluorophenyl) Carbamate
CAS:1057720-25-8
tert-butyl (2-bromo-6-fluorophenyl)carbamate Basic information
Product Name:tert-butyl (2-bromo-6-fluorophenyl)carbamate
Synonyms:tert-butyl (2-bromo-6-fluorophenyl)carbamate;tert-butyl N-(2-bromo-6-fluorophenyl)carbamate;Carbamic acid, N-(2-bromo-6-fluorophenyl)-, 1,1-dimethylethyl ester
CAS:1057720-25-8
MF:C11H13BrFNO2
MW:290.13
EINECS:
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Mol File:1057720-25-8.mol
tert-butyl (2-bromo-6-fluorophenyl)carbamate Structure
tert-butyl (2-bromo-6-fluorophenyl)carbamate Chemical Properties
Melting point 93-94 °C(Solv: ligroine (8032-32-4))
Boiling point 270.4±30.0 °C(Predicted)
density 1.459±0.06 g/cm3(Predicted)
pka11.85±0.70(Predicted)
Safety Information
MSDS Information
tert-butyl (2-bromo-6-fluorophenyl)carbamate Usage And Synthesis
Usestert-Butyl N-(2-Bromo-6-fluorophenyl)carbamate can be used in the preparation of indolines, isoquinolinones, and indoles by palladium-catalyzed annulation of substituted haloanilines or substituted halobenzamides with norbornadiene as an acetylene synthon. It can be useful in the preparation of ring-fluorinated N-Boc methyleneindolines via ortho lithiation and bromination of fluorinated anilines followed by nucleophilic addition of propargyl bromide and radical-induced ring closure. It can be useful in the synthesis of indoles via intramolecular 5-endo-dig carbocupration from N-aryl-ynamides.
tert-butyl (2-bromo-6-fluorophenyl)carbamate Preparation Products And Raw materials
Raw materials2-Bromo-6-fluorobenzoic acid-->tert-Butanol-->N-BOC-2-FLUOROANILINE
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