| Company Name: |
Shaanxi Dideu Medichem Co. Ltd
|
| Tel: |
029-81124267 15229202216 |
| Email: |
1073@dideu.com |
| Products Intro: |
Product Name:Azanidazole
CAS:62973-76-6
Package:25kg/桶/
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| | Azanidazole Basic information |
| Product Name: | Azanidazole | | Synonyms: | Azanidazole;2-Pyrimidinamine, 4-[(1E)-2-(1-methyl-5-nitro-1H-imidazol-2-yl)ethenyl]- | | CAS: | 62973-76-6 | | MF: | C10H10N6O2 | | MW: | 246.23 | | EINECS: | | | Product Categories: | | | Mol File: | 62973-76-6.mol |  |
| | Azanidazole Chemical Properties |
| Melting point | 232-235° | | Boiling point | 389.22°C (rough estimate) | | density | 1.3200 (rough estimate) | | refractive index | 1.7000 (estimate) |
| Toxicity | LD50 in mice, rats (mg/kg): 5100, 7600 orally; 590, 860 i.p. (Tammiso) |
| | Azanidazole Usage And Synthesis |
| Originator | Triclose,Ist. Chemioter.,Italy,1977 | | Uses | Antiprotozoal. | | Definition | ChEBI: Azanidazole is a member of imidazoles and a C-nitro compound. | | Manufacturing Process | Into a mixture of 1.6 g of 2-amino-4-methylpyrimidine with 10 ml of glacial
acetic acid is slowly added 2.13 g of concentrated sulfuric acid. A mixture of
2.4 g of 2-formyl-1-methyl-5-nitroimidazole in 20 ml of glacial acetic acid is
slowly added to the mixture of the pyrimidine under stirring. The reaction mixture is maintained at a temperature of about 55°C for 4 hours. The
resultant mixture is then diluted with 200 ml of distilled water and neutralized
with a saturated aqueous solution of sodium bicarbonate. A brownish-yellow
precipitate (MP 232° to 235°C) is formed and recovered. The product is
analyzed by infrared spectroscopy and is found to conform to 2-amino-4-[2-
(1-methyl-5-nitro-2-imidazolyl)vinyl]pyrimidine. | | Therapeutic Function | Antiprotozoal, Antibacterial | | Safety Profile | Moderately toxic byintraperitoneal route. Mildly toxic by ingestion.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits toxicfumes of NOx. |
| | Azanidazole Preparation Products And Raw materials |
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