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Product Name:ZLJ-6
CAS:1051931-39-5
Purity:98% Package:1G;10G;100G Remarks:ZLJ-6 is a dual inhibitor of COX and 5-lipoxygenase (5-LO) with IC50 values of 0.73, 0.31, and 0.99 μM for COX-1, COX-2, and 5-LO, respectively. It reduces carrageenin-induced paw edema (inflammatio
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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Product Name:ZLJ-6
CAS:1051931-39-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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MedBioPharmaceutical Technology Inc
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| Products Intro: |
Product Name:ZLJ-6
CAS:1051931-39-5
Purity:98% Package:25mg; 10mg; 5mg Remarks:Medbio
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| Product Name: | ZLJ-6 | | Synonyms: | ZLJ-6;ZLJ-6 Exclusive;QEJPXTVPNIOEHZ-VEZAGKLZSA-N | | CAS: | 1051931-39-5 | | MF: | C13H17N3O6S2 | | MW: | 375.421 | | EINECS: | | | Product Categories: | | | Mol File: | 1051931-39-5.mol |  |
| | ZLJ-6 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide | | form | crystalline solid |
| | ZLJ-6 Usage And Synthesis |
| Description | ZLJ-6 is a dual inhibitor of COX and 5-lipoxygenase (5-LO) (IC50 = 0.73, 0.31, and 0.99 μM for COX-1, COX-2, and 5-LO, respectively, in whole blood). It reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers, a common side effect of non-selective COX inhibitors. | | in vitro | zlj-6 was identified as a potent inhibitor of cyclooxygenase in human whole blood. it also inhibited the production of thromboxane b(2) and prostaglandin e(2) in calcium ionophore a23187-induced human and rat whole blood, and rat peritoneal leukocytes. zlj-6 suppressed the activity of 5-lipoxygenase in the rat basophilic leukemia (rbl-1) cell lysate and in intact cells and reduced the generation of leukotriene b(4) (ltb(4)) in a23187-stimulated human or rat whole blood, and rat peritoneal leukocytes [1]. | | in vivo | orally administered zlj-6 demonstrated potent anti-inflammatory activity in the carrageenin-induced paw oedema model in rats and showed analgesic activity in the acetic acid-induced abdominal construction model in mice. no gastrointestinal ulcers were found with the anti-inflammatory dose (30 mg/kg) in normal rats [1]. | | IC 50 | 0.73, 0.31, and 0.99 μm for cox-1, cox-2, and 5-lo, respectively | | references | [1] li, l. ,ji, h.,sheng, l., et al. the anti-inflammatory effects of zlj-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor. european journal of pharmacology 607 (1-3), 244-250 (2009). |
| | ZLJ-6 Preparation Products And Raw materials |
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