| Company Name: |
Haoyuan Chemexpress Co., Ltd.
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| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:Necrostatin 2
CAS:852391-19-6
Purity:>98% Package:650RMB/1mg
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| | 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Basic information |
| | 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Chemical Properties |
| density | 1.450±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | crystalline solid | | pka | 8.48±0.70(Predicted) |
| | 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Usage And Synthesis |
| Biological Activity | necrostatin 2 (nec-2) is a novel and potent necroptosis inhibitor with ec50 of 50 nm. it is an analog of necrostatin 1 (nec-1).necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented.nec-2 is efficacious in an animal model of ischemic stroke. many necroptosis inhibitor derivatives are designed for researchers. there is limited record for nec-2, but some reports are related with other necrostatins. nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase rip1 in vitro. | | target | RIPK2 | | references | [1]. teng x, keys h, jeevanandam a, structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. bioorg med chem lett. 2007 dec 15;17(24):6836-40. |
| | 2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-, (5R)- Preparation Products And Raw materials |
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