L-690,330
中文名称 | L-690,330 |
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中文同义词 | 化合物 T15685 |
英文名称 | L-690,330 |
英文同义词 | [1-(4-HYDROXYPHENOXY)ETHYLIDENE]BISPHOSPHONIC ACID;L-690,330;Phosphonic acid, P,P'-[1-(4-hydroxyphenoxy)ethylidene]bis-;L690330,L 690330 |
CAS号 | 142523-38-4 |
分子式 | C8H12O8P2 |
分子量 | 298.12 |
EINECS号 | |
相关类别 | |
Mol文件 | 142523-38-4.mol |
结构式 |
L-690,330 性质
沸点 | 696.9±65.0 °C(Predicted) |
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密度 | 1.787±0.06 g/cm3(Predicted) |
储存条件 | Store at RT |
溶解度 | 水:19.65(最大浓度 mg/mL);65.9(最大浓度 mM) |
酸度系数(pKa) | 1.44±0.10(Predicted) |
水溶解性 | Soluble to 20 mM in water |
Ki: 0.27 μM (Recombinant human IMPase), 0.19 μM (Recombinant bovine IMPase), 0.30 μM (Human frontal cortex IMPase), 0.42 μM (Bovine frontal cortex IMPase)
L-690330 (50 μM; 1 hour) induces P-AMPK and autophagy and increases LC3-I/II and p-AMPK expression in HEK293 cells.
Western Blot Analysis
Cell Line: | HEK293 cells |
Concentration: | 50 μM |
Incubation Time: | 1 hour |
Result: | Improved LC3-I/II and p-AMPK protein level. |
L-690330 (intracerebroventricular injection; 0.1 μmol) has no effects on their motor activity and coordination in the beam walking, except a reduction in time spent in light in the dark/light test.
Animal Model: | Eight-week-old male ICR mice |
Dosage: | 0.1 μmol |
Administration: | Intracerebroventricular injection |
Result: | Did not effect mice well-being by i.c.v injection. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101075 | L-690,330 L-690330 | 142523-38-4 | 10mM * 1mLin DMSO | 1760元 |
2024/04/30 | HY-101075 | L-690330 | 10 mg | 2600元 |