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| | ST072042 Basic information |
| Product Name: | ST072042 | | Synonyms: | 2-[(5-chloro-8-quinolyl)oxy]acetic acid ethyl ester;ethyl [(5-chloroquinolin-8-yl)oxy]acetate;ethyl 2-(5-chloroquinolin-8-yl)oxyacetate;ethyl 2-(5-chloroquinolin-8-yl)oxyethanoate;ethyl 2-[(5-chloro-8-quinolyl)oxy]acetate;ST072042;Acetic acid, 2-[(5-chloro-8-quinolinyl)oxy]-, ethyl ester;A2793 | | CAS: | 88349-90-0 | | MF: | C13H12ClNO3 | | MW: | 265.69 | | EINECS: | | | Product Categories: | | | Mol File: | 88349-90-0.mol |  |
| | ST072042 Chemical Properties |
| Boiling point | 393.4±27.0 °C(Predicted) | | density | 1.291±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 100 mg/mL (376.38 mM) | | pka | 1.97±0.29(Predicted) |
| | ST072042 Usage And Synthesis |
| Biological Activity | A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is a TWIK-related spinal cord potassium channel (TRESK, K2P18, KCNK18) and TASK-1 (KCNK3) with IC50 of 6.8 μM for mouse TRESK . | | in vitro | A2793 (100 μM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5).
It inhibits TASK-1 (100 μM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences TREK-1 and TALK-1.
A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1.
| | target | | Target | Value | mTRESK
(Cell-free assay) | 6.8 μM |
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| | ST072042 Preparation Products And Raw materials |
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