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Propargyl-PEG4-Tos

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Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:Propargyl-PEG4-Tos
CAS:875770-32-4
Package:1kg，2kg，5kg，10kg，25kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Propargyl-PEG4-Tos
CAS:875770-32-4
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Wuhan Borenpharm Co., Ltd
Tel: 027-65563561 18717150066
Email: 3207347307@qq.com
Products Intro: Product Name:Propargyl-PEG4-tos
Purity:0.95 Package:1g; 5g
Company Name: Hangzhou Huarong Pharm Co., Ltd.
Tel: 571-86758373 +8613588754946
Email: sales@huarongpharm.com
Products Intro: Product Name:Propargyl-PEG4-Tos
CAS:875770-32-4
Purity:0.99 Package:10MG,50MG,100MG,1G
Company Name: Jilin Chinese Academy of Sciences-yanshen Technology
Tel: +undefined18143011203
Email: info@chemextension.com
Products Intro: Product Name:Propargyl-PEG5-Tos
CAS:875770-32-4
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing

Propargyl-PEG4-Tos manufacturers

  • Propargyl-PEG5-Tos
  • Propargyl-PEG5-Tos pictures
  • $0.00 / 5g
  • 2024-03-26
  • CAS:875770-32-4
  • Min. Order: 5g
  • Purity: >95.00%
  • Supply Ability: 5g
Propargyl-PEG4-Tos Basic information
Product Name:Propargyl-PEG4-Tos
Synonyms:Propargyl-PEG4-Tos;Propargyl-PEG5-Tos;3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate);3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate
CAS:875770-32-4
MF:C18H26O7S
MW:386.46
EINECS:
Product Categories:
Mol File:875770-32-4.mol
Propargyl-PEG4-Tos Structure
Propargyl-PEG4-Tos Chemical Properties
Boiling point 498.1±45.0 °C(Predicted)
density 1.177±0.06 g/cm3(Predicted)
Safety Information
MSDS Information
Propargyl-PEG4-Tos Usage And Synthesis
DescriptionPropargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
Biological ActivityPropargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

PEGs

Cleavable

Propargyl-PEG4-Tos Preparation Products And Raw materials
Tag:Propargyl-PEG4-Tos(875770-32-4) Related Product Information
Propargyl-PEG5-t-butyl ester 2-[2-(2-Propyn-1-yloxy)ethoxy]acetic acid Polyethylene Glycol POLY(ETHYLENE GLYCOL) METHYL ETHER METHACRYLATE Propargyl-PEG9-bromide Propargyl-PEG8-acid Propargyl-PEG8-bromide Propargyl-PEG7-t-butyl ester Propargyl-PEG8-NHS ester Propargyl-PEG6-acid Propargyl-PEG8-t-butyl ester Propargyl-PEG6-t-butyl ester Propargyl-PEG7-acid Propargyl-PEG8-alcohol t-Boc-N-Amido-PEG2-Propargyl 2,5-dioxopyrrolidin-1-yl pent-4-ynoate MPEGn-Alkyne 2K, 5K, 10K, 20K Propargyl-PEG6-Tos