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| | TRC051384 Basic information |
| Product Name: | TRC051384 | | Synonyms: | TRC051384;TRC 051384; TRC-051384;N-[2-(4-Morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea;Urea, N-[2-(4-morpholinyl)ethyl]-N'-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]-;1-(2-Morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea;HSP,TRC-051384,TRC051384,Heat shock proteins,Inhibitor,inhibit | | CAS: | 867164-40-7 | | MF: | C25H31N5O4 | | MW: | 465.54 | | EINECS: | | | Product Categories: | API | | Mol File: | 867164-40-7.mol |  |
| | TRC051384 Chemical Properties |
| Boiling point | 685.7±55.0 °C(Predicted) | | density | 1.260±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in EtOH; insoluble in H2O; ≥109 mg/mL in DMSO | | form | solid | | pka | 13.47±0.46(Predicted) | | color | Yellow |
| | TRC051384 Usage And Synthesis |
| Uses | N-[2-(4-Morpholinyl)ethyl]-N''-[4-[3-[6-(4-morpholinyl)-2-pyridinyl]-1-oxo-2-propen-1-yl]phenyl]urea is a key reactant in the synthesis of TRC051384, which is a small molecule HSP70 inducer. | | Biological Activity | trc 051384, belonging to substituted 2-propen-1-one class, is a potent inducer of heat shock protein 70 (hsp70) [1]. induction of hsp70 is a natural response of stressed cells that protects neuronal cells from a variety of insults including acute ischemia. therefore, induction of hsp70 provides a potential target for the treatment of stroke [1]. | | in vitro | induction of hsp70 by trc 051384 (6.25, and 12.5 μm) involved heat shock factor-1 (hsf1) activation in hela cells and led to increasing chaperone and anti-inflammatory activity [1]. moreover, trc 051384 (10-50 μm) dose-dependently induced hspa1b overexpression in endothelial cells as well as leucocyte origin [2]. | | in vivo | trc 051384 (9 mg/kg, intra-peritoneal administration) treatment significantly decreased stroke-associated neuronal injury, disability, and increased survival in a rat model of transient ischemic stroke [1]. in addition, trc 051384 (9 mg/kg, intra-peritoneal administration) delayed thrombus formation without increasing bleeding risk in wt mice [2]. | | target | hsp70 | | references | 1. mohanan a, deshpande s, jamadarkhana pg, kumar p, gupta rc, chauthaiwale v, et al. delayed intervention in experimental stroke with trc 051384--a small molecule hsp70 inducer. neuropharmacology. 2011;60(6):991-9. 2. allende m, molina e, guruceaga e, tamayo i, gonzalez-porras jr, gonzalez-lopez tj, et al. hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk. cardiovasc res. 2016;110(3):309-18. |
| | TRC051384 Preparation Products And Raw materials |
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