| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:AS 19;(2S)-(+)-5-(1,3,5-TriMethylpyrazol-4-yl)-2-(diMethylaMino)tetralin
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
VDM Biochemicals
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| Tel: |
0330-2528181 |
| Email: |
sales@vdmbio.com |
| Products Intro: |
Product Name:AS 19
CAS:1000578-26-6
Purity:>=98%
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| | (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Basic information |
| Product Name: | (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN | | Synonyms: | AS 19;(2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN;2-Naphthalenamine, 1,2,3,4-tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-, (2S)-;(S)-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine;AS-19,AS19;(2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-4-pyrazolyl)-1,2,3,4-tetrahydronaphthalen-2-amine | | CAS: | 1000578-26-6 | | MF: | C18H25N3 | | MW: | 283.41 | | EINECS: | | | Product Categories: | Serotonin receptor;Potent 5-HT7 receptor agonist. | | Mol File: | Mol File |  |
| | (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Chemical Properties |
| Boiling point | 413.3±45.0 °C(Predicted) | | density | 1.09±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at -20°C | | solubility | <28.34mg/ml in ethanol; <28.34mg/ml in DMSO | | form | oil | | pka | 9.20±0.20(Predicted) | | color | Yellow |
| | (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Usage And Synthesis |
| Uses | A potent 5-HT7 receptor agonist | | Biological Activity | Reported potent 5-HT 7 receptor agonist (IC 50 = 0.83 nM). In vivo, enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia. | | storage | Desiccate at -20°C | | references | [1]. perez-garcía gs and meneses a. effects of the potential 5-ht7 receptor agonist as 19 in an autoshaping learning task. behav brain res, 2005, 163(1):136-40.
[2]. thomas dr and hagan jj. 5-ht7 receptors. current drug targets-cns & neurological disorders, 2004, 3(1): 81-90.
[3]. ulugol a, oltulu c, gunduz o, et al. 5-ht7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice. pharmacol biochem behav, 2012, 102(2):344-8.
[4]. león-ponte m, ahern gp and o'connell pj. serotonin provides an accessory signal to enhance t-cell activation by signaling through the 5-ht7 receptor. blood, 2007, 109(8):3139-46.
[5]. hoffman ms and mitchell gs. spinal 5-ht7 receptor activation induces long-lasting phrenic motor facilitation. j physiol, 2011, 589(pt 6):1397-407. |
| | (2S)-(+)-5-(1,3,5-TRIMETHYLPYRAZOL-4-YL)-2-(DIMETHYLAMINO)TETRALIN Preparation Products And Raw materials |
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