| Company Name: |
Shaanxi Istare Biotechnology Co., Ltd.
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| Tel: |
029-81530825 18682931470 |
| Email: |
2142355700@qq.com |
| Products Intro: |
Product Name:2-cyano-3-[4-(diphenylamino)phenyl]prop-2-enoic acid
CAS:30388-31-9
Purity:97% Package:100 mg, 250 mg, 1g
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| | 2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Basic information |
| | 2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Chemical Properties |
| Melting point | 213-214 °C | | Boiling point | 546.6±45.0 °C(Predicted) | | density | 1.280±0.06 g/cm3(Predicted) | | pka | -99.34±0.10(Predicted) |
| | 2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Usage And Synthesis |
| Description | DN-F01 is a potent cardiac sarcomere inhibitor, DNF01 targeting the cardiac muscle thin filament protein troponin complex. Functional studies show that DN-F01 has a strong inhibitory calcium-dependent effect on cardiac myofibrillar ATPase activity with an IC50 value of 11 ± 4 nmol/L. DN-F01 is shown to bind to a cardiac troponin C?troponin I chimera (cChimera) with a KD of ～50 nM using fluorescence spectroscopy, indicating that troponin is the likely target for DN-F01. NMR titrations of DNF01 to C35S and A-Cys cChimera show covalent and noncovalent binding of DN-F01 bound to the calcium-saturated cChimera. |
| | 2-Propenoic acid, 2-cyano-3-[4-(diphenylamino)phenyl]- Preparation Products And Raw materials |
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