Abciximab

Abciximab Suppliers list
Company Name: Beijing HuaMeiHuLiBiological Chemical   
Tel: 010-56205725
Email: waley188@sohu.com
Products Intro: Product Name:AbcixiMab
Company Name: Wuhan Chemstan Biotechnology Co., Ltd.  
Tel: 027-65317797 15926423062
Email: 422450190@qq.com
Products Intro: Product Name:Abciximab
Purity:>95%;1mg/ml Package:200ug;500ug;1mg
Company Name: J & J Medical & Distributors  
Tel: 08048954463
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Products Intro: Product Name:Abciximab
Company Name: Vaccure Pharma  
Tel: 08046071559
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Products Intro: Product Name:Abciximab
Company Name: Shanghai Yubo Biotechnology Co., Ltd.  
Tel: 021-51875103 15026509758
Email: 344843571@qq.com
Products Intro: Product Name:Abciximab
Abciximab Basic information
Product Name:Abciximab
Synonyms:Abciximab
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MW:0
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Abciximab Structure
Abciximab Chemical Properties
Safety Information
MSDS Information
Abciximab Usage And Synthesis
UsesMonoclonal antibody (antithrombotic).
Brand nameReoPro (Lilly).
General DescriptionAbciximab (ReoPro) is a chimeric Fabfragment monoclonal antibody that can bind to theGPIIa/IIIb receptor of platelets and block the ability offibrinogen to associate with the platelet. This results in lessplatelet aggregation. Abciximab is useful in treating unstableangina and as an adjunct to percutaneous coronaryintervention (PCI). The half-life of abciximab is about30 minutes, whereas its effects when bound to theGPIIa/IIIb may last up to 24 hours. A significant drawbackto using abciximab lies in its cost, which is approximately$1,500 for a single dose.
PharmacokineticsFor an adult patient, the usual dosing scheme is 0.25 mg/kg as an intravenous bolus given 10 to 60 minutes before percutaneous coronary intervention, followed by the continuous infusion of 0.125 μg/kg/minute for 12 hours to a maximum of 10 μg/kg. Elimination of abciximab is biphasic. The initial phase has a half-life of 10 minutes, whereas the half-life of the second phase is approximately 30 minutes and results from platelet binding. Platelet function returns to normal within 48 hours after infusion, even though abciximab is bound to circulating platelets for approximately 2 weeks。
Clinical UseAbciximab (ReoPro, chimeric) is an MAb engineered from theglycoprotein IIb/IIIa receptor of human platelets. The preparationis fragmented, containing only the Fab portion of theantibody molecule. This MAb is a chimeric human–mouseimmunoglobulin. The Fab fragments may contain mouse variableheavy- and light-chain regions and human constantheavy- and light-chain regions.
Abciximab is indicated as an adjunct to percutaneoustransluminal coronary angioplasty or atherectomy for theprevention of acute cardiac ischemic complications in patientsat high risk for abrupt closure of a treated coronaryvessel. Abciximab appears to decrease the incidence ofmyocardial infarction.
Abciximab binds to the intact GPIIb/GPIIIa receptor,which is a member of the integrin family of adhesion receptorsand the major platelet-specific receptors involved in aggregation.The antibody prevents platelet aggregation bypreventing the binding of fibrinogen, the von Willebrandfactor, and other adhesion molecules on activated platelets.The inhibition of binding to the surface receptors may be aresult of steric hindrance or conformational effects preventinglarge molecules from approaching the receptor.
Side effectsMany of the side effects of abciximab are due to its anti-platelet effects which increase the risk of bleeding. The most common type of bleeding due to abciximab is gastrointestinal hemorrhage.Thrombocytopenia is a rare but known serious risk characterized by a severe drop in platelets circulating in the blood. Abciximab induced thrombocytopenia is usually rapid occurring hours after administration but may occur up to 16 days later.Transfusing platelets is the only known treatment for abciximab-induced thrombocytopenia, but this therapy may have limited effectiveness because the drug may bind and inhibit the receptors on the newly transfused platelets.
Abciximab Preparation Products And Raw materials
Tag:Abciximab Related Product Information
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