| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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| Products Intro: |
Product Name:Anti-phospho-STAT3 (pTyr705) antibody produced in rabbit
Purity:affinity isolated antibody, buffered aqueous glycerol soluti Package:1VL Remarks:S2690-1VL
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| | ANTI-PHOSPHO-STAT3 (PTYR705) Basic information |
| Product Name: | ANTI-PHOSPHO-STAT3 (PTYR705) | | Synonyms: | ANTI-ACTIVATED STAT3 (TYR 705);ANTI-STAT3 (PHOSPHORYLATED) (PTYR705);ANTI-STAT3, PHOSPHO-SPECIFIC (TYR705), HUMAN;ANTI-STAT3 (PTYR705) MOUSE MAB;ANTI-STAT3 (PY705);ANTI-PHOSPHO-STAT3 (PTYR705);ANTI-PHOSPHO-STAT3 (Y705);Anti-APRF antibody produced in rabbit | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ANTI-PHOSPHO-STAT3 (PTYR705) Structure]() |
| | ANTI-PHOSPHO-STAT3 (PTYR705) Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous glycerol solution |
| | ANTI-PHOSPHO-STAT3 (PTYR705) Usage And Synthesis |
| Uses | Anti-phospho-STAT3 (pTyr705) antibody produced in rabbit has been used in immunohistochemical staining and immunoblotting. | | General Description | Signal transducer and activator of transcription 3 (STAT3) is a member of STAT family and it composed of 770 amino acids. The gene encoding protein consists of 24 exons and is extended over a length of 75170 bases on genomic DNA STAT3 is mapped on human chromosome 17q21.2. The protein is characterized with a conserved amino-terminal domain, a DNA-binding domain, an SH2 domain and a carboxy-terminal transactivation domain. | | Biochem/physiol Actions | Signal transducer and activator of transcription 3 (STAT3) plays a vital role in various cellular responses such as induction of an acute-phase response in hepatoma cells, stimulation of proliferation in B lymphocytes, activation of terminal differentiation and growth arrest in monocytes, and regulation of the pluripotency of embryonic stem cells. Activated STAT3 has been involved in malignant transformation. STAT3 may be a key player in the pathogenesis of diverse human cancers which makes this molecule a prime target for novel therapies. Phospho-tyrosine residue 705 (Tyr705) Stat3 can be used as a potential marker for determining overall survival of node-negative breast cancer patients. Phosphorylated STAT3 might be involved in angiogenesis, anti-apoptosis and tumor progression. |
| | ANTI-PHOSPHO-STAT3 (PTYR705) Preparation Products And Raw materials |
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