| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Oleoyl Serotonin
CAS:1002100-44-8
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:Oleoyl Serotonin
CAS:1002100-44-8
Purity:98% Package:100mg (solution); 50mg (solution); 10mg (solution) Remarks:Medbio
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:Oleoyl Serotonin;Inhibitor,TRP Channel,inhibit,Oleoyl Serotonin,Transient receptor potential channels
CAS:1002100-44-8
Purity:100.00% Package:10 mg;100 mg;200 mg;25 mg;5 mg;50 mg;500 mg
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| Company Name: |
Suzhou Zhixin Biotechnology Co., Ltd.
|
| Tel: |
0512-65118909 15162312715 |
| Email: |
sales@szzxbio.com |
| Products Intro: |
Product Name:OleoylSerotonin
CAS:1002100-44-8
Purity:98%+ Package:1g;10g;100g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Oleoyl Serotonin Exclusive
CAS:1002100-44-8
Purity:98% Package:10mg
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| | Oleoyl Serotonin Basic information |
| Product Name: | Oleoyl Serotonin | | Synonyms: | Oleoyl Serotonin;(Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]octadec-9-enamide;Oleoyl Serotonin Exclusive;9-Octadecenamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-, (9Z)-;Inhibitor,TRP Channel,inhibit,Oleoyl Serotonin,Transient receptor potential channels | | CAS: | 1002100-44-8 | | MF: | C28H44N2O2 | | MW: | 440.66 | | EINECS: | | | Product Categories: | | | Mol File: | 1002100-44-8.mol |  |
| | Oleoyl Serotonin Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤15mg/ml in DMSO;15mg/ml in dimethyl formamide | | form | solution in ethanol. |
| | Oleoyl Serotonin Usage And Synthesis |
| Definition | ChEBI: N-oleoylserotonin is an N-acylserotonin obtained by formal condensation of the carboxy group of oleoic acid with the primary amino group of serotonin. It is functionally related to an oleic acid. | | Biological Activity | oleoyl serotonin is a trpv1 antagonist with ic50 value of 2.57 μm for human trpv1 [1].the transient receptor potential vanilloid-type 1 (trpv1) channel is a nonselective cation channel that may be activated by a variety of exogenous and endogenous physical and chemical stimuli. trpv1 is decreased in the injured nerve fibers but increased in those proximal to the site damage. trpv1 is a potential new target for the development of analgesic and anti-inflammatory drugs [1].oleoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. arachidonoyl serotonin is a dual antagonist of trpv1 and fatty acid amide hydrolase (faah) with ic50 values of 0.27 and 8 μm, respectively. arachidonoyl serotonin was highly effective against both acute and chronic peripheral pain [1][2]. in trpv1 and faah assays, oleoyl serotonin inhibited anandamide hydrolysis by faah and capsaicin-induced intracellular ca2+ elevation in hek293 cells overexpressing the human recombinant trpv1 receptor with ic50 values of > 50 μm and 2.57 μm, respectively [1]. | | references | [1]. ortar g, cascio mg, de petrocellis l, et al. new n-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. j med chem. 2007 dec 27;50(26):6554-69.
[2]. maione s, de petrocellis l, de novellis v, et al. analgesic actions of n-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid trpv1 receptors. br j pharmacol. 2007 mar;150(6):766-81. |
| | Oleoyl Serotonin Preparation Products And Raw materials |
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